Circulating vascular endothelial growth factor and systemic inflammatory markers in patients with stable and exacerbated chronic obstructive pulmonary disease
- 3 September 2008
- journal article
- Published by Portland Press Ltd. in Clinical Science
- Vol. 115 (7), 225-232
- https://doi.org/10.1042/cs20070382
Abstract
The aim of the present study was to assess circulating levels of VEGF (vascular endothelial growth factor), a biomarker with prognostic significance in cardiovascular disease, and markers of systemic inflammation in patients with stable and exacerbated COPD (chronic obstructive pulmonary disease). Lung function parameters, arterial blood gas analysis and circulating levels of VEGF, IL-6 (interleukin-6), TNF-α (tumour necrosis factor-α), CRP (C-reactive protein), fibrinogen and the peripheral blood neutrophil cell count were assessed in 30 patients on admission to the hospital for acute exacerbation of COPD, in 30 age-, gender- and BMI (body mass index)-matched patients with stable COPD, and 30 matched controls with normal lung function. Patients with acute exacerbated COPD had higher circulating concentrations of VEGF (PPPPr=0.61, Pr=0.46; Pr=0.39, P1 (forced expiratory volume in 1 s) (r=0.47, P<0.01). Recovery from the exacerbation resulted in a significant decrease in both circulating VEGF levels and markers of systemic inflammation. In conclusion, circulating levels of VEGF and markers of systemic inflammation are up-regulated in patients with acute exacerbated COPD and decrease after recovery from the exacerbation.Keywords
This publication has 40 references indexed in Scilit:
- Increased expression of placenta growth factor in COPDThorax, 2008
- Rhinovirus infects primary human airway fibroblasts and induces a neutrophil chemokine and a permeability factorJournal of Medical Virology, 2005
- Enhanced bronchial expression of vascular endothelial growth factor and receptors (Flk-1 and Flt-1) in patients with chronic obstructive pulmonary diseaseThorax, 2005
- Serum vascular markers and vascular imaging in assessment of rheumatoid arthritis disease activity and response to therapyRheumatology, 2005
- Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysisThorax, 2004
- Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paperEuropean Respiratory Journal, 2004
- Platelet activation, coagulation and angiogenesis in breast and prostate carcinomaThrombosis and Haemostasis, 2004
- Prognostic Significance of Angiogenic Growth Factor Serum Levels in Patients With Acute Coronary SyndromesCirculation, 2003
- Serial Measurement of Vascular Endothelial Growth Factor and Transforming Growth Factor-β1 in Serum of Patients With Acute Ischemic StrokeStroke, 2000
- Interleukin 6 Induces the Expression of Vascular Endothelial Growth FactorJournal of Biological Chemistry, 1996