Absorption and Excretion of Water and Salt Following Autonomic Blockade (TEAC) in the Dog: Chronic Renal Denervation

Abstract

Autonomic blockade induced in dogs by TEAC has a variable effect on water and salt excretion depending on the state of hydration of the animal. Given during active water diuresis, TEAC has an antidiuretic effect, sodium excretion remaining roughly proportional to urine flow. In hydropenic dogs, diuresis and natriuresis are induced. This effect is temporarily abolished by renal denervation, or by a sham operation, but returns. Production of blockade before administration of a water load results in a 2-hr. delay in diuresis. This effect is uninfluenced by renal denervation and is apparently due to failure of intestinal absorption of water. There is no appreciable effect of chronic renal denervation on the basal excretion of Na and water in the hydropenic dog.