Inhibition of electron transport of rat liver mitochondria by unnatural (‐)‐antimycin A3
- 4 November 1991
- journal article
- Published by Wiley in FEBS Letters
- Vol. 292 (1-2), 61-63
- https://doi.org/10.1016/0014-5793(91)80834-p
Abstract
The inhibition of electron transport by unnatural (‐)‐antimycin A3 was examined with rat liver mitochondria and compared with that of natural (+)‐antimycin A3. (−)‐Antimycin A3 inhibited respiration about 1/100th as strongly as natural (+)‐antimycin A3. (−)‐Antimycin A3 binding to the cytochromebc1 complex did not seem to induce a conformational change in this proteinous complex. The binding site of (−)‐antimycin A3 was probably the same as that of (+)‐antimycin A3 (at the Qi center). However, the mode of interaction with the Qi center by (−)‐antimycin A3 and (+)‐antimycin A3 was somewhat different.Keywords
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