Maintenance of Globulin Levels in X-irradiated Rabbits after Immunization

Abstract

Rabbits were injected with antigen 24 hours after x-irradiation. Antibody titers were correlated with relative changes in gamma-beta globulin levels determined electrophoretically. Irradiated, immunized rabbits did not form detectable antibodies but had significantly greater globulin levels than non-immunized, irradiated controls. This relative difference occurred at the time nonirradiated, immunized rabbits were producing primary antibody.