Radioactively labelled epoxides. Part III. Tritium labelled steroid 16α, 17α‐epoxides

Abstract

Tritium labelled (17‐³H) 16α, 17α‐epoxy‐androst‐4‐en‐3‐one and 16α, 17α‐epoxy‐estra‐1,3,5(10)‐trien‐3‐ol have been prepared on a large scale (200‐300 mg amounts) with efficient (i.e. activity of product exactly predictable) introduction of label. The preparative method is very inexpensive, since the tritium derives from tritiated water, the steroid starting materials are readily available, and high yields are obtained in all steps.