Effect of cannabinoids on the abdominal constriction response in mice: within cannabinoid interactions
- 1 January 1976
- journal article
- Published by Springer Nature in Psychopharmacology
- Vol. 46 (1), 83-85
- https://doi.org/10.1007/bf00421553
Abstract
After oral administration to mice, δ 9-tetrahydrocannabinol (THC) and cannabinol (CBN) caused a dosedependent suppression of the abdominal constriction response to formic acid. Cannabinol was 50 times less active than THC and cannabidiol (CBD) was without effect. The effects of THC and CBN were additive. CBD antagonised the antinociceptive effects of both THC and CBN in a dose-dependent manner.Keywords
This publication has 23 references indexed in Scilit:
- INTERACTION OF CANNABIS AND GENERAL ANAESTHETIC AGENTS IN MICEBritish Journal of Pharmacology, 1974
- Interaction of Δ9-tetrahydrocannabinol and cannabidiol on intestinal motility in miceJournal of Pharmacy and Pharmacology, 1974
- The effect of cannabinoids on intestinal motility and their antinociceptive effect in miceBritish Journal of Pharmacology, 1973
- Prostaglandins and cannabis—II inhibition of biosynthesis by the naturally occurring cannabinoidsBiochemical Pharmacology, 1973
- Inhibition of prostaglandin E2 biosynthesis by Δ1-tetrahydrocannabinolProstaglandins, 1972
- Analgesic potency and acute toxicity of substituted anilides and benzamidesToxicology and Applied Pharmacology, 1971
- THE ABDOMINAL CONSTRICTION RESPONSE AND ITS SUPPRESSION BY ANALGESIC DRUGS IN THE MOUSEBritish Journal of Pharmacology, 1968
- CONDITIONS INFLUENCING THE INHIBITION, BY ANALGESIC DRUGS, OF THE RESPONSE TO INTRAPERITONEAL INJECTIONS OF PHENYLBENZOQUINONE IN MICEBritish Journal of Pharmacology and Chemotherapy, 1965
- Release of a kinin by intraperitoneal injection of chemical agents in miceInternational Journal of Neuropharmacology, 1964
- Phenylquinone Writhing Test : Interpretation of DataNature, 1963