Synergistic effect of A23187 and a phorbol ester on amylase secretion from rabbit pancreatic acini
- 7 May 1984
- journal article
- Published by Wiley in FEBS Letters
- Vol. 170 (1), 64-68
- https://doi.org/10.1016/0014-5793(84)81369-1
Abstract
The combination of the ionophore A23187 and the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) stimulates amylase secretion from rabbit pancreatic acini up to a level equal to, or slightly higher than when carbachol is used as stimulant. Each of the two compounds alone gives only a minor stimulation. This synergistic effect of A23187 and TPA supports a role of protein kinase C in pancreatic enzyme secretion.Keywords
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