An Interferon-sensitive Early Step in the Establishment of Infection of Murine Cells by Murine Sarcoma/Leukaemia Virus
- 1 April 1979
- journal article
- research article
- Published by Microbiology Society in Journal of General Virology
- Vol. 43 (1), 173-181
- https://doi.org/10.1099/0022-1317-43-1-173
Abstract
Human cytomegalovirus (HCMV) infection of low serum-arrested confluent whole human embryo (Flow 5000) cells markedly stimulated ornithine decarboxylase (ODC) activity. Increased ODC activity was apparent by 12 h post-infection. The capacity of HCMV to stimulate ODC was: (1) dependent upon multiplicity of infection; (2) eliminated when the virus was neutralized with specific antiserum; and (3) sensitive to ultraviolet irradiation. Virus-mediated induction, in contrast to high serum induction of ODC, was not subject to inhibition by polyamines added to the growth medium.This publication has 8 references indexed in Scilit:
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