ADULT RENAL OSTEITIS FIBROSA WITH METASTATIC CALCIFICATION AND HYPERPLASIA OF ONE PARATHYROID GLAND

Abstract

LONG-STANDING renal disease with accompanying hyperplasia of the parathyroid glands and osteitis fibrosa is a rare syndrome which only in recent years has been adequately described from the clinical and pathologic viewpoints with at least partial clarification of the pathogenesis. Because of its unusually interesting clinical and pathologic features, particularly in children, the disorder has formed the basis of a number of reports dealing with young persons. It is not appreciated so well, however, that a similar syndrome may occur in the adult. Lucas¹in 1883 first noted the association of albuminuria and rickets, and Fletcher²in 1911 described skeletal changes in children with long-standing renal dysfunction. The condition has subsequently been described under various designations, such as renal rickets and renal dwarfism. These children showed either decrease or cessation of growth, with skeletal deformities and enlargement of the bones at the endochondral junctions. Because of the similarity