Sympathetic denervation causes atrial natriuretic peptide-storing granules to appear in the ventricular myocardium of the rat
- 1 August 1990
- journal article
- research article
- Published by Springer Nature in Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
- Vol. 342 (2), 241-244
- https://doi.org/10.1007/bf00166971
Abstract
Sympathetic denervation of the rat heart was produced by 6-hydroxydopamine. In denervated ventricles abundant “atrial” granules were observed whereas in controls no such granules were seen. Denervated ventricles and atria showed a very high content of atrial natriuretic peptide-like immunoreactivity (> 10 times higher than in control animals). We suggest that the sympathetic nervous system exerts a repressive effect upon synthesis of atrial natriuretic peptide-like material and upon the formation of atrial natriuretic peptide-storing granules in the ventricular myocardium.Keywords
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