Failure to confirm association of a polymorphism in ABCB1 with multidrug-resistant epilepsy
- 28 September 2004
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 63 (6), 1090-1092
- https://doi.org/10.1212/01.wnl.0000137051.33486.c7
Abstract
Alteration of ATP-binding cassette subfamily B member 1 transporter (ABCB1) can plausibly cause drug-resistant epilepsy as it influences brain penetration of drugs. The CC genotype at the ABCB1 C3435T polymorphism was reported to be associated with multidrug resistance. A replication study in 401 drug-resistant and 208 drug-responsive subjects with epilepsy showed no significant association between the CC genotype and drug-resistant epilepsy. The authors suggest the initial association may have arisen by chance.Keywords
This publication has 11 references indexed in Scilit:
- Insulin-like Growth Factor I, Insulin-like Growth Factor Binding Protein 3, and Urologic Measures of Benign Prostatic HyperplasiaAmerican Journal of Epidemiology, 2003
- Association of Multidrug Resistance in Epilepsy with a Polymorphism in the Drug-Transporter GeneABCB1New England Journal of Medicine, 2003
- Is Refractory Epilepsy Due to Genetically Determined Resistance to Antiepileptic Drugs?New England Journal of Medicine, 2003
- Problems of reporting genetic associations with complex outcomesThe Lancet, 2003
- Reporting, Appraising, and Integrating Data on Genotype Prevalence and Gene-Disease AssociationsAmerican Journal of Epidemiology, 2002
- Role of Multidrug Transporters in Pharmacoresistance to Antiepileptic DrugsPublished by American Society for Pharmacology & Experimental Therapeutics (ASPET) ,2002
- Parameters for reliable results in genetic association studies in common diseaseNature Genetics, 2002
- Replication validity of genetic association studiesNature Genetics, 2001
- Genetic association studiesNeurology, 2001
- A Consumer's Guide to Subgroup AnalysesAnnals of Internal Medicine, 1992