Influence of ofloxacin, norfloxacin, nalidixic acid, pyromidic acid and pipemidic acid on human γ-interferon production and blastogenesis

Abstract

Several new quinolone derivatives were investigated for their influence on human lymphocyte blastogenesis and γ-interferon production following concanavalin A stimulation. All the antimicrobials induced inhibition of lymphocyte DNA synthesis. The γ-interferon measurements showed that nalidixic acid and norfloxacin have a negative influence on lymphokine poduction and release.