Evaluation of Zimeldine in Alzheimer's Disease
- 1 August 1985
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 42 (8), 744-748
- https://doi.org/10.1001/archneur.1985.04210090008003
Abstract
• Neuropsychological and neurochemical effects of zimeldine, a relatively specific serotonin reuptake blocker, were examined in four patients with clinically diagnosed Alzheimer's disease, in a double-blind, placebo-controlled, crossover study. Individualized doses of zimeldine were administered to achieve target plasma zimeldine concentrations of approximately 50 (low) to 100 (high) ng/mL. Overall, there was no significant effect of zimeldine on memory or reaction time measures as compared with placebo. The drug significantly reduced (by up to 38%) 5-hydroxyindoleacetic acid concentrations in the cereobrospinal fluid and almost abolished (90% reduction) platelet serotonin uptake. Cerebrospinal fluid concentrations of 3-methoxy-4-hydroxyphenylglycol, a major metabolite of norepinephrine, and homovanillic acid, the major metabolite of dopamine, were not altered. Our findings indicate that alterations in central and peripheral serotoninergic function by a serotonin reuptake blocker (zimeldine) are unaccompanied by measurable changes in memory and/or reaction time in patients presumed to have Alzheimer's disease.This publication has 21 references indexed in Scilit:
- Assessing the noradrenergic system in normal aging: A review of methodologyExperimental Aging Research, 1983
- Choline chloride effects on memory in the elderly☆Neurobiology of Aging, 1980
- Plasma levels of chlorimipramine and its demethyl metabolite during treatment of depressionClinical Pharmacology & Therapeutics, 1979
- Enhancement of Memory by PhysostigmineNew England Journal of Medicine, 1979
- Straight-Phase Ion-Pair Chromatography of Zimelidine and Similar Divalent Amines Part I BioanalysisJournal of Liquid Chromatography, 1979
- Effect of diet on urinary MHPG excretion in depressed patients and normal control subjectsAmerican Journal of Psychiatry, 1977
- Initial clinical trial based on biochemical methodology of zimelidine (a serotonin uptake inhibitor) in depressed patientsClinical Pharmacology & Therapeutics, 1977
- Observations on the brains of demented old peopleJournal of the Neurological Sciences, 1970
- The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly SubjectsThe British Journal of Psychiatry, 1968
- Distribution of Alzheimer's neurofibrillary changes in the brain stem and hypothalamus of senile dementiaActa Neuropathologica, 1966