Human neuroblastoma cells produce the NF‐kB‐like HIV‐1 transcription activator during differentiation
- 26 April 1993
- journal article
- Published by Wiley in FEBS Letters
- Vol. 321 (2-3), 201-204
- https://doi.org/10.1016/0014-5793(93)80108-7
Abstract
Human neuroblastoma GOTO and IMR32 cells differentiate into neural cells on treatment with 5-BrdU. Here we report that in association with differentiation induced by 5-BrdU, the transcription of HIV-1 was activated in both neuroblastoma cell lines. An NF-kB-like factor was also found to be produced in association with the neural cell differentiation of these cells. These results suggest that, during differentiation of neural cells, an NF-kB-like factor was produced, and that when the neural cells are infected with HIV-1 the production of NF-kB results in activation of transcription of HIV-1. Thus this NF-kB-like factor may be involved in the mechanism causing AIDS dementiaKeywords
This publication has 16 references indexed in Scilit:
- Activation of HIV gene expression during monocyte differentiation by induction of NF-kBNature, 1989
- The involvement of NF-κB in β-interferon gene regulation reveals its role as widely inducible mediator of signal transductionCell, 1989
- Human immunodeficiency virus can productively infect cultured human glial cells.Proceedings of the National Academy of Sciences, 1987
- An inducible transcription factor activates expression of human immunodeficiency virus in T cellsNature, 1987
- Demonstration of virus-specific transcriptional activator(s) in cells infected with HTLV-III by an in vitro cell-free systemCell, 1986
- Multiple nuclear factors interact with the immunoglobulin enhancer sequencesCell, 1986
- Trans -Activator Gene of Human T-Lymphotropic Virus Type III (HTLV-III)Science, 1985
- Detection, Isolation, and Continuous Production of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and Pre-AIDSScience, 1984
- Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)Science, 1983
- Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nucleiNucleic Acids Research, 1983