Multiple modes of engrailed regulation in the progression towards cell fate determination
- 1 August 1991
- journal article
- Published by Springer Nature in Nature
- Vol. 352 (6334), 404-410
- https://doi.org/10.1038/352404a0
Abstract
The engrailed gene product of Drosophila specifies the fate of a subset of cells in each segment. Our studies of engrailed regulation suggest that fate determination is an elaborate, multistep process. At the time in embryogenesis when the engrailed-dependent cell fate is probably determined, four modes of control act in an overlapping progression to govern engrailed expression. After activation by pair-rule genes, both an extracellular signal, wingless, and autoregulation are required for engrailed expression. Autoregulation graduates to wingless independence, but is transient, and is superseded by an engrailed- independent mode of maintenance.Keywords
This publication has 29 references indexed in Scilit:
- Distribution of the wingless gene product in drosophila embryos: A protein involved in cell-cell communicationCell, 1989
- Positive autoregulation of the myogenic determination gene MyoD1Cell, 1989
- polyhomeotic: a gene required for the embryonic development of axon pathways in the central nervous system of Drosophila.Genes & Development, 1988
- The Drosophila homology of the mouse mammary oncogene int-1 is identical to the segment polarity gene winglessCell, 1987
- The engrailed locus of drosophila: In situ localization of transcripts reveals compartment-specific expressionCell, 1985
- The engrailed locus of drosophila: Structural analysis of an embryonic transcriptCell, 1985
- Transposition of Cloned P Elements into Drosophila Germ Line ChromosomesScience, 1982
- Compartments in the wing of Drosophila: A study of the engrailed geneDevelopmental Biology, 1976
- Developmental compartmentalization in the dorsal mesothoracic disc of DrosophilaDevelopmental Biology, 1976
- Genetic Control of Wing Disc Development in DrosophilaNovartis Foundation Symposia, 1975