Igm and igg anti‐f(ab )2 antibodies in rheumatoid arthritis and systemic lupus erythematosus

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Abstract
Radioimmunoassays for anti‐F(ab )2 antibodies, which feature the use of goat anti‐human Fc antibody for correcting potentiation of IgM anti‐F(ab )2 antibody titers by endogenous IgM anti‐Fc antibodies (rheumatoid factors), are described. Individuals with classic rheumatoid arthritis had significantly more IgM anti‐F(ab )2 antibody (P < 0.001) and IgG anti‐F(ab )2 antibody (P = 0.05) than did individuals with systemic lupus erythematosus or normal volunteers. There is some similarity in patterns of isotype distribution of anti‐F(ab )2 antibodies and rheumatoid factors.
Funding Information
  • National Institutes of Health (AM-26409)