Distribution of 2,2 (p-Chlorophenyl) 1,1,1 Trichlorethane (DDT) in Tissues of Rats after Its Ingestion.

Abstract

The DDT contents of the liver, kidney, brain and adrenals of rats fed diets containing 0.1% and 0.2% DDT were detd. at various intervals. The amts. of this agent stored in the respective tissues reach a maximum within a few days and remain at a constant level in animals fed 0.1% DDT. The greatest concn. was noted in the adrenals. The concns. of DDT in the brain, liver, and kidneys of rats fed 0.2% DDT increase slightly and progressively with time. The concn. of this material is markedly increased in the adrenal at the time when the animals are severely intoxicated.