Effect of calcium on in vitro activity of LY146032 against Clostridium difficile
- 1 March 1987
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 31 (3), 461-462
- https://doi.org/10.1128/aac.31.3.461
Abstract
The in vitro MICs of LY146032 against 63 isolates of Clostridium difficile tested in Wilkins-Chalgren broth ranged from 0.5 to greater than 32 micrograms/ml, with MICs of 4 and 8 micrograms/ml for 50 and 90% of the isolates, respectively. However, when the test medium was supplemented with physiologic concentrations of calcium, the MIC for 90% of the isolates was reduced to less than or equal to 0.12 microgram/ml.This publication has 2 references indexed in Scilit:
- In vitro activity and mechanism of action of A21978C1, a novel cyclic lipopeptide antibioticAntimicrobial Agents and Chemotherapy, 1985
- Medium for Use in Antibiotic Susceptibility Testing of Anaerobic BacteriaAntimicrobial Agents and Chemotherapy, 1976