DIABETOGENIC, THYROTROPIC, ADRENOTROPIC AND PARATHYROTROPIC FACTORS OF THE PITUITARY

Abstract

Note.— This article and the articles in the previous issues ofThe Journalare part of a series published under the auspices of the Council on Pharmacy and Chemistry. Other articles will appear in succeeding issues ofThe Journal. When completed, this series will be published in book form.—Ed. I. DIABETOGENIC SUBSTANCE Numerous observations made both in the clinic and in the laboratory are to be found in the literature of the last few years which indicate either directly or indirectly that the pituitary gland may influence definitely the metabolism of both carbohydrate and fat; for this reason there has been a growing conviction that the pituitary has some endocrine relationship with the pancreatic islets or their secretion. Borchardt¹noted the frequent occurrence of glycosuria in acromegaly, and this was confirmed by Goetsch, Cushing and Jacobson.²More recently, Houssay³and Eidelsberg⁴have called attention to the frequent occurrence of