It may be said that the basic treatment of tetanus is to prevent the extension of the disease and to neutralize the toxins already present. However, at the time the diagnosis of tetanus becomes apparent, certain dangerous and sometimes fatal symptoms are already established. Rigidity and spasm of muscle must be controlled in order to prevent death due to either exhaustion or respiratory failure. In the past various agents, such as magnesium sulfate, the barbiturates, chloral hydrate and tribromoethanol (avertin®), have been used. In more recent years muscle-relaxing agents such as various preparations of curare and curare-like drugs have been tried. In Charity Hospital at New Orleans the Anesthesia Department is consulted in cases of tetanus in reference to resuscitative measures and the use and administration of muscle-relaxing agents and sedative drugs such as tribromoethanol. From July 1, 1947 to the time of writing we have been consulted in regard