Cholinergic Vesicles: Ability to Empty and Refill Independently of Cytoplasmic Acetylcholine
- 6 January 1978
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 199 (4324), 85-86
- https://doi.org/10.1126/science.199.4324.85
Abstract
Incubation of minced mouse-forebrain tissues in lithium Krebs solution reduces the acetylcholine content of the vesicular fraction 70 percent without altering that of the cytoplasmic fraction. Depleted vesicular-bound acetylcholine can be restored with newly synthesized acetylcholine (formed from extracellular choline) independently of the cytoplasmic pool. Depletion of vesicular-bound acetylcholine does not facilitate the movement of preformed extracellular-acetylcholine into vesicles.This publication has 13 references indexed in Scilit:
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