Asymmetric carbon–carbon bond‐forming reaction at the 2‐position of a piperidine skeleton
- 25 November 2002
- Vol. 15 (1), 89-94
- https://doi.org/10.1002/chir.10151
Abstract
An asymmetric carbon–carbon bond-forming reaction at the 2-position of a piperidine skeleton was exploited. This method consisted of a reaction between 1-(4-methoxybenzoyl)-3,4-didehydro-2-methoxypiperidines and dimethyl malonate catalyzed by Cu(II)-chiral 2,2′-isopropylidenebis(4-phenyl-2-oxazoline) to afford a 2-substituted piperidine skeleton with moderate enantioselectivity. Chirality 15:89–94, 2003.Keywords
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