DEXAMETHASONE EFFECT ON BLOOD-BRAIN BARRIER DAMAGE CAUSED BY ACUTE HYPERTENSION IN X-IRRADIATED RABBITS

Abstract
Unilateral X-ray exposure of brain increases the vulnerability of cerebral vessels to acute hypertension in the brain hemisphere exposed to radiation. A preventive effect of dexamethasone was observed when treatment with the drug was started before irradiation; but also when the drug was given 24 h before acute hypertension was induced, 1 week after irradiation.