Kinins, beta-adrenergic receptors and functional vasodilatation in the submaxillary gland of the cat

Abstract

The close arterial infusion of bradykinin into the submaxillary gland of the cat produced a pronounced hyperemia that could be blocked by simultaneous perfusion of the gland with blood containing carboxypeptidase B. Carboxypeptidase B, however, failed to reduce the vasodilatation of chorda tympani nerve stimulation suggesting that the kinins are not involved in the regulation of submaxillary gland blood flow. Isoproterenol injections produced pronounced salivary gland vasodilatation. Beta-adrenergic blocking drugs reduced or abolished the hyperemia of isoproterenol and reduced that of chorda tympani nerve stimulation. The combination of beta-blocking drugs and atropine could abolish or reduce further this nerve induced hyperemia. Stimulation of cholinergic and beta-adrenergic receptors could account for the chorda tympani induced hyperemia.