Nucleoside Inhibitors of Zika Virus
- 27 May 2016
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 214 (5), 707-711
- https://doi.org/10.1093/infdis/jiw226
Abstract
There is growing evidence that Zika virus (ZIKV) can cause devastating infant brain defects and other neurological disorders in humans. However, no specific antiviral therapy is available at present. We tested a series of 2′-C- or 2′-O-methyl–substituted nucleosides, 2′-C-fluoro-2′-C-methyl–substituted nucleosides, 3′-O-methyl–substituted nucleosides, 3′-deoxynucleosides, derivatives with 4′-C-azido substitution, heterobase-modified nucleosides, and neplanocins for their ability to inhibit ZIKV replication in cell culture. Antiviral activity was identified when 2′-C–methylated nucleosides were tested, suggesting that these compounds might represent promising lead candidates for further development of specific antivirals against ZIKV.Keywords
Funding Information
- Czech Science Foundation (grantGA14–29256S)
- Ministry of Education, Youth, and Sports of the Czech Republic, under the NPU I program (grant LO1218)
- National Subvention for the Development of Research Organizations (61388963)
- European Virus Archive goes Global (grant 653316)
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