Tolerance of Skin Homografts Induced in Adult Mice by Multiple Injections of Homologous Spleen Cells.

Abstract

Summary 1. Adult mice of the Z(C3H) strain have been made tolerant of skin homo-grafts of the(A X Z) F₁ hybrid strain by repeated intravenous and intraperitoneal injections of homologous spleen cells. 2. Repeated intraperitoneal injections of homologous spleen cells generally failed to induce a tolerant state, although 3/75 recipients accepted the homologous skin homotransplant.