Irritability in Autistic Children Treated with Fenfluramine
- 21 July 1983
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 309 (3), 187
- https://doi.org/10.1056/nejm198307213090317
Abstract
To the Editor: A report by Geller et al. presented preliminary results suggesting the possible usefulness of fenfluramine (a substituted phenylethylamine widely used as an appetite suppressant) in the treatment of infantile autism (July 15, 1982, issue).1 The rationale for the use of this agent rests on its ability to lower peripheral-blood levels of serotonin and on the observation that a substantial minority of autistic persons have elevated peripheral-blood serotonin levels.2 The report emphasized the preliminary nature of the results in a small sample of three young autistic boys with elevated serotonin levels. We have seen two cases in which . . .Keywords
This publication has 4 references indexed in Scilit:
- The double-blind in danger: untoward consequences of informed consentAmerican Journal of Psychiatry, 1982
- Preliminary Observations on the Effect of Fenfluramine on Blood Serotonin and Symptoms in Three Autistic BoysNew England Journal of Medicine, 1982
- Hyperserotonemia and Amine Metabolites in Autistic and Retarded ChildrenArchives of General Psychiatry, 1977
- Fenfluramine poisoningThe Journal of Pediatrics, 1975