TUMOR PROMOTION AND INDUCTION OF EPIDERMAL ORNITHINE DECARBOXYLASE ACTIVITY IN MECHANICALLY STIMULATED MOUSE SKIN
- 1 January 1978
- journal article
- research article
- Vol. 38 (3), 494-497
Abstract
Wounding by incision was a promoting stimulus in mouse skin previously initiated with 7,12-dimethylbenz(a)anthracene. Skin massage elicited a marked proliferative response in skin but was not a promoting stimulus. Wounding mouse skin, by multiple scalpel incisions or stripping with silicon carbide paper, led to a marked induction of ornithine decarboxylase activity. In both instances activity was maximal between 20 and 26 h after wounding, with a secondary rise at 72 h. Skin massage did not lead to a detectable increase in ornithine decarboxylase activity over the same time period.This publication has 3 references indexed in Scilit:
- Ornithine Decarboxylase May Function as an Initiation Factor for RNA Polymerase IScience, 1977
- RELATIONSHIP BETWEEN POLYAMINE ACCUMULATION AND DNA-REPLICATION IN SYNCHRONIZED CHINESE-HAMSTER OVARY CELLS AFTER HEAT SHOCK1977
- Alpha-methyl ornithine, a potent competitive inhibitor of ornithine decarboxylase, blocks proliferation of rat hepatoma cells in culture.Proceedings of the National Academy of Sciences, 1976