Chronic treatment with antidepressants: Potentiation of clonidine-induced aggression in mice via noradrenergic mechanism
- 1 September 1981
- journal article
- research article
- Published by Springer Nature in Journal of Neural Transmission
- Vol. 52 (3), 189-197
- https://doi.org/10.1007/bf01249603
Abstract
The chronic (10mg/kg i.p. twice daily, 10 days)-and not the acute-administration of amitriptyline, maprotiline or zimelidine enhances aggressiveness induced by clonidine in mice. An analogous potentiation of clonidine-induced aggressiveness was obtained with chronic administration (the schedule as above) of levomepromazine (2 mg/kg) or thioridazine (5 mg/kg) but not of spiperone (0.2 mg/kg). Fluoxetine (10 mg/kg), atropine (5 mg/kg), propranolol (10 mg/kg) or metergoline (0.5 mg/kg) given chronically (the schedule as above) also had no effect. The enhancement of clonidine aggressiveness induced by prolonged treatment with imipramine (10 mg/kg) was prevented by cycloheximide, an inhibitor of protein synthesis. The results supply further evidence for the previously proposed hypothesis that chronic administration of antidepressants enhances the responsiveness of central postsynaptic noradrenaline receptors.This publication has 25 references indexed in Scilit:
- Anti-aggressive Effect of Zimelidine in Isolated MiceActa Pharmacologica et Toxicologica, 2009
- Interaction Studies between Three Antidepressant Drugs (Chlorimipramine, Imipramine and Zimelidine) and Noradrenaline, Tyramine and Vagal Stimulation on the Heart Rate and Blood Pressure in DogsActa Pharmacologica et Toxicologica, 2009
- Facilitated shock-induced aggression after chronic treatment with antidepressant drugs in the ratPharmacology Biochemistry and Behavior, 1981
- Effects of chronic administration of antidepressant drugs on aggressive behavior induced by clonidine in micePharmacology Biochemistry and Behavior, 1980
- Hypersensitivity of the climbing behaviour response to apomorphine induced by a short depression of dopaminergic neurone activityNeuropharmacology, 1979
- The effect of repeated administration of antidepressant drugs on the responsiveness of rats to catecholamine agonistsJournal of Neural Transmission, 1979
- The effects of chronic treatment with the 5-hydroxytryptamine uptake blocker zimelidine on central 5-hydroxytryptamine mechanisms. Evidence for the induction of a low affinity binding site for 5-hydroxytryptamineNeuroscience Letters, 1979
- Central Antiserotonin Action of AmitriptylinePharmacopsychiatry, 1979
- Neuropharmacological and related aspects of animal aggressionProgress in Neuro-Psychopharmacology, 1978
- Neuroleptic drug interactions with norepinephrine alpha receptor binding sites in rat brainNeuropharmacology, 1977