Middle cerebral artery occlusion as a cause of isolated subcortical infarction.

Abstract

Two patients with large subcortical hemispheric infarctions were reported located in areas prone to the development of lacunes, who had occlusion of the middle cerebral artery demonstrated by arteriography. The cortical vessels were perfused by leptomeningeal collaterals. Large vessel arterial disease should be considered as a possible etiology of large subcortical infarctions and the term lacune should not be used in cases in which neither the size nor the pathophysiologic mechanism of the lesion conform to description.