Preparation of a specific antibody to methamphetamine.

Abstract

N-Carboxymethylmethamphetamine (III) was synthesized directly from methamphetamine (I), an antihypnotic agent, and through a new route starting from ephedrine. This new hapten was conjugated with BSA [bovine serum albumin] and the antiserum for I was prepared by immunization of rabbits with the conjugate. The production of the antibody for I was confirmed by the ring test and Ouchterlony method.