Effective blocking of HIV‐1 proteinase activity by characteristic inhibitors of aspartic proteinases
- 10 April 1989
- journal article
- Published by Wiley in FEBS Letters
- Vol. 247 (1), 113-117
- https://doi.org/10.1016/0014-5793(89)81251-7
Abstract
Inhibitory constants (K i) between 5 and 35 nM were derived (under different conditions of pH and ionic strength) for the interaction of HIV-1 proteinase with acetyl-pepstatin and H-261, two characteristic inhibitors of aspartic proteinases. Thus this enzyme, essential for replication of the AIDS virus, may be classified unequivocally as belonging to this proteinase family.Keywords
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