Singlet oxygen induces collagenase expression in human skin fibroblasts
- 4 October 1993
- journal article
- Published by Wiley in FEBS Letters
- Vol. 331 (3), 304-306
- https://doi.org/10.1016/0014-5793(93)80357-z
Abstract
Singlet oxygen generated in a dark reaction by thermodissociation of an endoperoxide (NDPO2) elicits an increase in mRNA of interstitial collagenase (MMP-1) in cultured human fibroblasts. The effect is enhanced in deuterium oxide-based medium and is abolished in the presence of non-toxic doses of sodium azide. In contrast, the mRNA level of the tissue inhibitor of metalloproteinases (TIMP-1) remains unaltered under these experimental conditions. These observations support the suggestion that an unbalanced synthesis of collagenase and TIMP reported to occur following UV-A irradiation or during inflammatory conditions may be mediated by singlet oxygen.Keywords
This publication has 21 references indexed in Scilit:
- UVA-Induced Autocrine Stimulation of Fibroblast-Derived-Collagenase by IL-6: A Possible Mechanism in Dermal Photodamage?Journal of Investigative Dermatology, 1993
- Ultraviolet A Irradiation Stimulates Collagenase Production in Cultured Human FibroblastsJournal of Investigative Dermatology, 1992
- Awakenings ... UV Light and HIV Gene ActivationScience, 1992
- INCREASED TRANSCRIPTION AND TRANSLATION OF HEME OXYGENASE IN CHINESE HAMSTER FIBROBLASTS FOLLOWING PHOTODYNAMIC STRESS OR PHOTOFRIN II INCUBATIONPhotochemistry and Photobiology, 1991
- SINGLET OXYGEN INVOLVEMENT IN THE INACTIVATION OF CULTURED HUMAN FIBROBLASTS BY UVA (334 nm, 365 nm) AND NEAR‐VISIBLE (405 nm) RADIATIONSPhotochemistry and Photobiology, 1989
- Singlet oxygen production by biological systemsChemico-Biological Interactions, 1989
- DNA damage by oxygen radicals and excited state species: A comparative study using enzymatic probes in vitroChemico-Biological Interactions, 1988
- 12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced gene sequences in human primary diploid fibroblasts and their expression in SV40-transformed fibroblastsJournal of Cellular Biochemistry, 1985
- Variability in Collagen and Fibronectin Synthesis by Scleroderma Fibroblasts in Primary CultureJournal of Investigative Dermatology, 1981