Residual dipolar couplings as new conformational restraints in isotopically 13C‐enriched oligosaccharides
- 25 September 1998
- journal article
- Published by Wiley in FEBS Letters
- Vol. 436 (1), 128-130
- https://doi.org/10.1016/s0014-5793(98)01112-0
Abstract
We report the measurement of residual dipolar couplings for 13C‐enriched NeuNAcα2‐3Galβ1‐4Glc in a dilute liquid‐crystalline medium. These couplings provide long‐range conformational restraints that hitherto have not been available for oligosaccharides. We utilise these restraints in dynamical simulated annealing calculations, which support current models of the solution behaviour of the trisaccharide.Keywords
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