Serum amyloid A protein, apolipoprotein A-I, and apolipoprotein B during the course of acute myocardial infarction.
Open Access
- 1 December 1988
- journal article
- research article
- Published by BMJ in Journal of Clinical Pathology
- Vol. 41 (12), 1263-1268
- https://doi.org/10.1136/jcp.41.12.1263
Abstract
Serum amyloid A protein (SAA), apolipoprotein A-I (apoA-I), apolipoprotein B (apoB) concentrations, and creatine kinase (CK)-MB isoenzyme activity were serially measured in 10 patients during the course of acute myocardial infarction. Pronounced increases in SAA concentrations were observed in all patients during infarction. The highest SAA values were observed, on average, 67 hours after the onset of chest pain. After infarction both apoA-I and apoB concentrations decreased. The reduction in apoA-I concentration 67 to 72 hours after the onset of chest pain was (31%) (p less than 0.01) and the reduction in apoB concentration 55 to 60 hours after the onset of pain was (34%) (p less than 0.01). Negative correlations were found between the concentrations of SAA and apoproteins A-I and B; this inverse relation was stronger between SAA and apoB than between SAA and apo-AI.This publication has 31 references indexed in Scilit:
- Serum amyloid A concentrations during the course of acute ischaemic heart disease.Journal of Clinical Pathology, 1986
- Human High-density Lipoprotein Associated Amyloid a Protein: Structural Characteristics, Relation to Apo A-I and A-II Concentrations, and Plasma Clearance Kinetics in the RatScandinavian Journal of Rheumatology, 1985
- Appearance of serum amyloid protein in high-density lipoproteins of rabbits subjected to relatively mild stimuliBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1984
- Is Interferon an Inducer of Serum Amyloid A?New England Journal of Medicine, 1983
- Plasma clearance kinetics of the amyloid-related high density lipoprotein apoprotein, serum amyloid protein (apoSAA), in the mouse. Evidence for rapid apoSAA clearance.JCI Insight, 1983
- THE BIOLOGY OF SAA: IDENTIFICATION OF THE INDUCER, IN VITRO SYNTHESIS, AND HETEROGENEITY DEMONSTRATED WITH MONOCLONAL ANTIBODIES*Annals of the New York Academy of Sciences, 1982
- Monokine-induced synthesis of serum amyloid A protein by hepatocytesNature, 1980
- Serum Amyloid AJCI Insight, 1978
- Isolation and characterization of two threonine-poor apolipoproteins of human plasma high density lipoproteinsBiochemistry, 1978
- Connective tissue origin of the amyloid-related protein SAA.The Journal of Experimental Medicine, 1976