Chronic malarial infection in Balb/c mice. Effect on the immune response to sheep erythrocytes and histological changes in the liver and spleen
- 31 December 1975
- journal article
- research article
- Published by Oxford University Press (OUP) in Transactions of the Royal Society of Tropical Medicine and Hygiene
- Vol. 69 (5-6), 468-470
- https://doi.org/10.1016/0035-9203(75)90099-1
Abstract
Chronic malarial infection was established in Balb/c mice by following Plasmodium berghei yoelii with P.b. berghei infection. It was found that the IgG plaque-forming cell response to sheep erythrocytes was depressed for at least six months. A preliminary investigation of the histological changes in the spleen and liver is described. The possibility that chronically infected mice could serve as a model for the tropical splenomegaly syndrome is discussed.Keywords
This publication has 8 references indexed in Scilit:
- Humoral Immune Responses in the Tropical-Splenomegaly Syndrome in New GuineaClinical Science, 1972
- Clinical Trial of Malaria Prophylaxis in Tropical Splenomegaly SyndromeBMJ, 1971
- Acquired immunity to Plasmodium berghei yoelii in miceTransactions of the Royal Society of Tropical Medicine and Hygiene, 1971
- Studies of splenomegaly in rodent malaria II. The course of splenomegaly, IgM, IgG levels and IgG immunofluorescent antibody titre in mice after infection with plasmodium berghei yoelii and/or plasmodium chabaudiTransactions of the Royal Society of Tropical Medicine and Hygiene, 1971
- Tropical Splenomegaly Syndrome: Long-term Proguanil Therapy Correlated with Spleen Size, Serum IgM, and Lymphocyte TransformationBMJ, 1970
- The Immunodepressive Effect of a Murine Plasmodium and its Interaction with Murine Oncogenic VirusesJournal of General Microbiology, 1969
- The tropical splenomegaly syndromeTransactions of the Royal Society of Tropical Medicine and Hygiene, 1968
- Cross-immunity between the malaria parasites of rodentsPathogens and Global Health, 1966