THERE are numerous reports in the literature concerning abnormal hepatic function and pathologic changes in the liver of patients with thyrotoxicosis. As a result, there is prevalent a notion that the liver is frequently involved by the thyrotoxic state, both functionally and structurally. It is to be noted, however, that the clinical data are quite inadequate or scanty in most, if not all, series of cases reported as demonstrating anatomical abnormalities in the liver of such patients. Moreover, the pathologic changes as described are the ones observed exclusively in the autopsy material. Thus, the possibility that such abnormalities might be due to some complicating or coexistent conditions has not been adequately ruled out. Also it is obvious that the pathologic changes in the liver as described have been seen only in those patients who were so gravely ill as to die, either from the hyperthyroid state per se or from