THE ACTIONS OF FLUPENTHIXOL UPON 5‐HYDROXYTRYPTAMINE‐INDUCED AGGREGATION AND THE UPTAKE OF 5‐HYDROXYTRYPTAMINE AND DOPAMINE BY HUMAN BLOOD PLATELETS
Open Access
- 1 December 1975
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 55 (4), 555-557
- https://doi.org/10.1111/j.1476-5381.1975.tb07432.x
Abstract
The effects of the α- and β-isomers of flupenthixol on 5-hydroxytryptamine (5-HT)-induced platelet aggregation and on 5-HT and dopamine uptake were investigated. α-Flupenthixol was 185 times more potent than the β-isomer as an inhibitor of platelet aggregation. In contrast both isomers were equipotent as inhibitors of uptake of 5-HT and dopamine. The data suggest that 5-HT-induced aggregation and uptake are separate processes.Keywords
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