THE IN VITRO INACTIVATION OF PITRESSIN BY NORMAL AND CIRRHOTIC HUMAN LIVER 1
Open Access
- 1 December 1954
- journal article
- research article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 33 (4), 549-554
- https://doi.org/10.1172/jci102925
Abstract
The normal water loaded dog was used for the assay of antidiuretic activity remaining after incubation of Pitressin with a cell free homogenate of liver. The homogenate of normal liver regularly inactivated 0.90 milliunits Pitressin/mg. of tissue. In 8 of 9 assays the homogenate obtained from cirrhotic liver inactivated 0.88-0.90 milliunits Pitressin/mg. of tissue. This finding supports the impression that impaired destruction of antidiuretic hormone is not an important factor in the fluid retention associated with hepatic cirrhosis.Keywords
This publication has 12 references indexed in Scilit:
- THE EFFECTS OF PITRESSIN ON THE METABOLISM AND EXCRETION OF WATER AND ELECTROLYTES IN NORMAL SUBJECTS AND PATIENTS WITH CIRRHOSIS AND ASCITES 12JCI Insight, 1952
- STUDIES IN EDEMA. III. THE EFFECT OF PITRESSIN ON THE RENAL EXCRETION OF WATER AND ELECTROLYTES IN PATIENTS WITH AND WITHOUT LIVER DISEASE 12JCI Insight, 1951
- Water and Electrolyte Metabolism in Congestive Heart FailureCirculation, 1951
- The role of water and salt in the development of heart failure.1951
- The antidiuretic action of the hepatic vasodepressor ferritin (VDM) and its occurrence in conditions associated with antidiuresis in man.1950
- The excretion of antidiuretic hormone in the urine of patients with cirrhosis of the liver.1950
- INACTIVATION OF POSTERIOR PITUITARY ANTIDIURETIC HORMONE BY THE LIVER1Endocrinology, 1949
- WATER STORAGE AND THE MOVEMENTS OF BODY FLUIDS AND CHLORIDES DURING ACUTE LIVER DISEASEJCI Insight, 1947
- FACTORS INFLUENCING ASCITES IN PATIENTS WITH CIRRHOSIS OF THE LIVER 1JCI Insight, 1945
- The fate of the antidiuretic principle of postpituitary extracts in vivo and in vitro1The Journal of Physiology, 1935