Endogenous Creatinine Clearance

Abstract

FOR many years crcatinine clearance has been used as an estimate of glomerular filtration rate. In 1926 Rehberg¹ first suggested that exogenous creatinine clearance could be used for this purpose. Shannon,² however, in 1935, demonstrated exogenous creatinine clearance at high plasma levels of creatinine to be greater than inulin, because of tubular excretion of some creatinine at these high levels. Two years later Popper and Mandel³ first suggested the use of endogenous creatinine clearance (C_cr) as a measure of glomerular filtration rate. In 1938 Miller and Winkler⁴ were able to measure accurately the normal low serum levels of . . .