Testing Susceptibility of Multidrug-Resistant Mycobacterium tuberculosis to Second-Line Drugs by Use of Blood Agar
- 1 November 2010
- journal article
- research article
- Published by American Society for Microbiology in Journal of Clinical Microbiology
- Vol. 48 (11), 4291-4293
- https://doi.org/10.1128/jcm.00688-10
Abstract
In this study, the susceptibilities of 35 multidrug-resistant (MDR) Mycobacterium tuberculosis clinical isolates to second-line drugs, including kanamycin (KM), rifabutin (RBU), ofloxacin (OFX), p -aminosalicylic acid (PAS), capreomycin (CAP), clofazimine (CFM), and ethionamide (ETH), were investigated on blood agar according to CLSI recommendations. Compared with the results of the Bactec 460 TB system, agreement was 100, 100, 97, 100, 100, 100, and 86% for KM, RBU, OFX, PAS, CAP, CFM, and ETH, respectively. Compared with the results of the proportion method, agreement was 100, 100, 97, 100, 97, 100, and 77% for KM, RBU, OFX, PAS, CAP, CFM, and ETH, respectively.Keywords
This publication has 13 references indexed in Scilit:
- Multicenter Evaluation of Bactec MGIT 960 System for Second-Line Drug Susceptibility Testing of Mycobacterium tuberculosis ComplexJournal of Clinical Microbiology, 2009
- Extensively Drug-Resistant Tuberculosis: A New Face to an Old PathogenAnnual Review of Medicine, 2009
- Comparative Study for Determination of Mycobacterium tuberculosis Susceptibility to First- and Second-Line Antituberculosis Drugs by the Etest Using 7H11, Blood, and Chocolate AgarJournal of Clinical Microbiology, 2008
- Evaluation of Blood Agar for Susceptibility Testing ofMycobacterium tuberculosisagainst First-Line Antituberculous Drugs: Results from Two CentersJournal of Chemotherapy, 2008
- Cost-Effectiveness of Blood Agar for Isolation of MycobacteriaPLoS Neglected Tropical Diseases, 2007
- Susceptibilities of Mycobacterium tuberculosis to Isoniazid and Rifampin on Blood AgarJournal of Clinical Microbiology, 2005
- Evaluation of Moxifloxacin ActivityIn VitroAgainstMycobacterium tuberculosis, Including Resistant and Multidrug-Resistant StrainsJournal of Chemotherapy, 2004
- Rapid alternative methods for detection of rifampicin resistance in Mycobacterium tuberculosisJournal of Antimicrobial Chemotherapy, 2004
- Blood Agar and Mycobacterium tuberculosis : the End of a DogmaJournal of Clinical Microbiology, 2003
- IndexClinical Microbiology Newsletter, 1992