Relative iron deficiency in hereditary spherocytosis
- 1 June 1989
- journal article
- research article
- Published by Wiley in American Journal of Hematology
- Vol. 31 (2), 81-86
- https://doi.org/10.1002/ajh.2830310202
Abstract
Seventy-three patients with hereditary spherocytosis (HS) (58 nonsplenectomized, 15 splenectomized) were studied to evaluate iron status and the adequacy of iron availability for erythropoiesis. Splenectomized patients, who had hemoglobin levels in the normal or upper normal range, had higher levels of serum iron, transferrin saturation, and serum ferritin than normal matched controls and normal zinc protoporphyrin (ZnPP) levels. On the contrary, nonsplenectomized patients presenting with mild to severe anemia had higher red cell ZnPP concentrations than both splenectomized subjects and matched normal controls. ZnPP in nonsplenectomized patients correlated inversely with Hb concentration, mean corpuscular volume (MCV), mean red cell hemoglobin concentration (MCHC), transferrin saturation, and serum iron, and directly with reticulocyte count. At multiple regression analysis only Hb concentration was a significant explanatory variable for high ZnPP. The authors conclude that a number of nonsplenectomized HS patients have relative iron deficiency primarily because of expansion of erythropoiesis caused by anemia.Keywords
This publication has 18 references indexed in Scilit:
- GENETIC HAEMOCHROMATOSIS AND CONGENITAL SPHEROCYTOSISThe Lancet, 1987
- Association of Hereditary Spherocytosis and Idiopathic Hemochromatosis: A Synergistic Effect in Determining Iron OverloadAmerican Journal of Clinical Pathology, 1986
- Increased Red Blood Cell Protoporphyrin in Thalassemia: A Result of Relative Iron DeficiencyAmerican Journal of Clinical Pathology, 1984
- Iron loading in congenital dyserythropoietic anaemias and congenital sideroblastic anaemiasBritish Journal of Haematology, 1983
- Iron overload in hereditary spherocytosis: Association with hla‐linked hemochromatosisAmerican Journal of Hematology, 1982
- Acidified Glycerol Lysis Test: a Screening Test for SpherocytosisBritish Journal of Haematology, 1980
- IRON ABSORPTION AND LOADING IN β-THALASSÆMIA INTERMEDIAThe Lancet, 1979
- HEREDITARY SPHEROCYTOSIS WITH SECONDARY HÆMOCHROMATOSISThe Lancet, 1968
- Hemochromatosis after prolonged oral iron therapy in a patient with chronic hemolytic anemiaAmerican Journal Of Medicine, 1953
- HÆMOCHROMATOSIS IN THREE FAMILIES AND IN A WOMANThe Lancet, 1949