Fentanyl-Air-Oxygen Anesthesia for Ligation of Patent Ductus Arteriosus in Preterm Infants

Abstract

In 10 premature infants (1123 ± 263 g), fentanyl citrate (30 to 50 μg/kg) was used in conjunction with pancuronium (0.1 mg/kg) as the sole anesthetic for transthoracic ligation of patent ductus arteriosus. Ventilation was controlled with air and oxygen in concentrations sufficient to maintain transcutaneous Po₂ between 50 and 70 torr. Circulatory stability was easily maintained throughout the procedure. “Stiff chest” was avoided by the use of muscle relaxants, and the infants were awake within 1 hour after the procedure.