Influence of diet on transamidinase activity in dystrophic mice

Abstract

The activities of the enzymes involved in creatine synthesis were studied in normal and dystrophic mice maintained on two commercial mouse chows. Kidney transamidinase activity in the dystrophic mouse was found to vary from 150 to –50% of the normal depending on the diet fed while the activity of the enzyme in the control mice remained unaltered. Addition of protein or glycine to the diet normally causing the lower transamidinase values resulted in increased enzyme levels equal to those found in animals maintained on the diet normally producing the higher enzyme levels.