Genetically Determined Sex-Reversal in 46,XY Humans
- 6 October 1978
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 202 (4363), 53-56
- https://doi.org/10.1126/science.567843
Abstract
Evidence is presented for the existence of a gene, probably on the X chromosome, which prevents testis differentiation when present in 46,XY human embryos. Affected 46,XY women are not completely normal because of premature ovarian involution, as a result of which they have "streak gonads" similiar to those of 45,X women.Keywords
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