Major psychosis and dopamine: controversial features and some suggestions
- 1 February 1984
- journal article
- research article
- Published by Cambridge University Press (CUP) in Psychological Medicine
- Vol. 14 (4), 779-789
- https://doi.org/10.1017/s0033291700019759
Abstract
Synopsis Three problems with the dopamine hypothesis of major psychosis are pointed out: the long time-course of neuroleptic therapy; the absence of tolerance to the antipsychotic effects of neuroleptic drugs, or of a supersensitivity psychosis on drug withdrawal; and the absence of potent psychotogenic properties in the direct dopamine agonists. A resolution of these paradoxes is suggested relying on a role for dopamine in learning processes at a relatively high (cognitive) functional level. The hypothesis proposed is also used to explain the origin of some of the more distinctive psychotic symptoms.Keywords
This publication has 65 references indexed in Scilit:
- The role of dopamine in locomotor activity and learningBrain Research Reviews, 1983
- Increased concentrations and lateral asymmetry of amygdala dopamine in schizophreniaNature, 1983
- Differential Effects of Classical and Atypical Antipsychotic Drugs on A9 and A10 Dopamine NeuronsScience, 1983
- Pimozide Blocks Establishment But Not Expression of Amphetamine-Produced Environment-Specific ConditioningScience, 1983
- THERAPEUTIC WINDOW FOR PLASMA HALOPERIDOL IN ACUTE SCHIZOPHRENIC PSYCHOSISThe Lancet, 1983
- DOPAMINE RECEPTORS AND SCHIZOPHRENIA: DRUG EFFECT OR ILLNESSThe Lancet, 1980
- Dopaminergic A10 neurones are involved in cognitive functionsNature, 1980
- Antischizophrenic drugs: Differential plasma protein binding and therapeutic activityLife Sciences, 1979
- INCREASED DOPAMINE-RECEPTOR SENSITIVITY IN SCHIZOPHRENIAThe Lancet, 1978
- Differential effects of neuroleptic and other psychotropic agents on acquisition of avoidance in ratsLife Sciences, 1976