Effect of Homologous Blood Components and Heterologous Lysed Red Blood Cells on Dog Renal Dynamics.

Abstract

The effects on glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) of homologous blood component and heterologous lysed red blood cells have been studied in dogs. The renal vasoconstriction associated with peripheral intravenous infusion of homologous lysed red blood cells in dogs is caused primarily by hemoglobin although the red blood cell stroma appears to have an additive effect. Peripheral intravenous infusion of heterologous lysed red blood cells of human, cow, horse, and sheep origin cause a significant decrease in GFR and ERPF in dogs. Portal vein infusion of heterologous lysed red blood cells through the liver causes a significant decrease in GFR and ERPF in dogs and is frequently associated with moderate decrease in arterial blood pressure. These experiments suggest that the protection afforded the kidney by initial passage of homologous red cell lysates through the liver is due to specific modification of the hemoglobin, a process the liver is unable to perform with heterologous red cell lysates.