Public and individual idiotopes in the anti‐poly(Glu60,Ala30,Tyr10) response: analysis by monoclonal antibodies
- 1 January 1983
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 13 (12), 1023-1030
- https://doi.org/10.1002/eji.1830131214
Abstract
From BALB/c mice immunized with anti‐GAT monoclonal antibody (mAb) G5, we have obtained anti‐idiotypic mAb against individual (or private) idiotopes, expressed by G5 as well as anti‐GAT mAb, that are heteroclitic because they recognize poly(Glu50,Tyr50) (GT) better than poly(Glu60,Ala30,Tyr10) (GAT). From BALB/c mice immunized with BALB/c polyclonal anti‐GAT antibodies, anti‐idiotypic mAb directed against public idiotopes expressed following GAT immunization in all individuals of all mouse strains tested have been obtained. Nine anti‐idiotypic mAb were studied in detail. One of these mAb recognizes only polyclonal anti‐GAT antibodies; the other eight recognize polyclonal anti‐GAT antibodies and anti‐GAT mAb. The distribution of the structures recognized by the different anti‐idiotypic mAb on a battery of 20 anti‐GAT mAb allows definition of two families of public idiotopes.This publication has 29 references indexed in Scilit:
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