Antifibrillating Action of N-Methyl-Dibenzyl-Amine and Some of Its Derivatives

Abstract

The antifibrillating activity of a series of tertiary bases with a carbon skeleton related to the possible chemical structure of [alpha]-fagarine was assayed in rabbits. Of these, 8 were derivatives of methyldibenzylamine by addition of either methyoxylic or dimethylenic groups to the aromatic nuclei. The others, also chemically related, were ethyl-dibenzyl-amine, methyl-benzylanisidine and methyl-phenetyl-amine. All showed antifibrillating activity, but [alpha]-fagarine showed the maximal effect. The addition of methoxylic groups enhanced the effect against fibrillation of the ventricle and the addition, of dimethylenic group against fibrillation of the auricle.