Reversible Inhibition of Mitosis in Lymphocyte Cultures by Non-Viable Mycoplasma.

Abstract

Summary Sufficiently concentrated non-viable Mycoplasma hominis type I suspensions will inhibit the mitogenic action of phytohemagglutin in lymphocyte cultures. The inhibition can be reversed by removing the PPLO as late as 48 hours after inoculation. Mitosis can be started with PHA, stopped by PPLO, and restarted without additional PHA by changing the medium.